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Combination of AURKA inhibitor and HSP90 inhibitor to treat breast cancer with AURKA overexpression and TP53 mutations.

Medical oncology (Northwood, London, England) - 7 Sept 2022

Wang Fuping, Zhang Haotian, Wang Haitao, Qiu Tian, He Binghong, Yang Qiong

Abstract excerpt

Breast cancer is the most common cancer among women worldwide. Researches show that Aurora kinase A (AURKA) is highly expressed in approximately 73% of breast cancer patients, which induces drug resistance in breast cancer patients and decreases the median survival time. AURKA regulates spindle assembly, centrosome maturation, and chromosome alignment. AURKA overexpression affects the occurrence and development...

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PMID: 36071247
DOI: 10.1007/s12032-022-01777-x

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