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Article

Colorectal cancer-associated SNP rs17042479 is involved in the regulation of NAF1 promoter activity.

PloS one - 1 Jan 2022

Olsson Josephine B, Gugerel Marietta B, Jessen Stine B, Jørgensen Jannie, Gögenur Ismail, Hansen Camilla, Kirkeby Lene T, Olsen Jørgen, Pedersen Ole B V, Vestlev Peter M, Dahlgaard Katja, Troelsen Jesper T

Abstract excerpt

A novel risk locus at 4q32.2, located between the Nuclear Assembly Factor 1 (NAF1) and Follistatin Like 5 (FSTL5) genes, was associated with increased risk of developing colorectal cancer (CRC), with SNP rs17042479 being the most associated. However, the link between CRC development and the risk locus at 4q32.2 is unknown. We investigated the promoter activity of NAF1 and FSTL5 and analyzed the risk locus at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36067202
DOI: 10.1371/journal.pone.0274033
PMCID: PMC9447907

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