Article
Methodology established for the detection of circulating tumor DNA by hybridization capture.
BioTechniques - 1 Sept 2022
Yao Xumei, Zhou Zhilin, Xie Yuancai, Huang Zhigang, Lu Shixin, Liu Chaoyu, Wang Jun, Li Xiaohua
Abstract excerpt
Roche's AVENIO ctDNA analysis kits and bioinformatics analysis (the AVENIO system) are accessible to all NGS laboratories. We have developed an approach, namely the Sec-Seq system, and compared the accuracy, sensitivity, repeatability and economic cost between the AVENIO system and the Sec-Seq system. Both methods share the comparable accuracy and sensitivity in detecting the variant allele frequency of 0.0005,...
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