Article
Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen.
Nature communications - 5 Sept 2022
Washizaki Ayaka, Murayama Asako, Murata Megumi, Kiyohara Tomoko, Yato Keigo, Yamada Norie, Aly Hussein Hassan, Tanaka Tomohisa, Moriishi Kohji, Nishitsuji Hironori, Shimotohno Kunitada, Goh Yasumasa, Ishii Ken J, Yotsuyanagi Hiroshi, Muramatsu Masamichi, Ishii Koji, Takahashi Yoshimasa, Suzuki Ryosuke, Akari Hirofumi, Kato Takanobu
Abstract excerpt
Although the current hepatitis B (HB) vaccine comprising small-HBs antigen (Ag) is potent and safe, attenuated prophylaxis against hepatitis B virus (HBV) with vaccine-escape mutations (VEMs) has been reported. We investigate an HB vaccine consisting of large-HBsAg that overcomes the shortcomings of the current HB vaccine. Yeast-derived large-HBsAg is immunized into rhesus macaques, and the neutralizing...
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