Article
IDH1R132H Promotes Malignant Transformation of Benign Prostatic Epithelium by Dysregulating MicroRNAs: Involvement of IGF1R-AKT/STAT3 Signaling Pathway.
Neoplasia (New York, N.Y.) - 1 Feb 2018
Zhang Lili, Qi Mei, Feng Tingting, Hu Jing, Wang Lin, Li Xinjun, Gao Wei, Liu Hui, Jiao Meng, Wu Zhen, Bai Xinnuo, Bie Yifan, Liu Long, Han Bo
Abstract excerpt
Risk stratification using molecular features could potentially help distinguish indolent from aggressive prostate cancer (PCa). Mutations in isocitrate dehydrogenase (IDH) acquire an abnormal enzymatic activity, resulting in the production of 2-hydroxyglutarate and alterations in cellular metabolism, histone modification, and DNA methylation. Mutant IDH1 has been identified in various human malignancies, and...
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