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Circulating tumor DNA in colorectal cancer: biology, methods and applications

1 Apr 2025

Abstract excerpt

In the practice of colorectal cancer (CRC), traditional tumor tissue analysis is limited by intratumoral and intertumoral heterogeneity and its invasive nature. Circulating tumor DNA (ctDNA) analysis, a promising liquid biopsy approach, has been increasingly explored in clinical studies. Biologically, ctDNA is characterized by tumor-specific diversity and rapid clearance from circulation, enabling real-time,...

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PMID: 40167831
DOI: 10.1007/s12672-025-02220-z

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