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Genome-wide in vivo screen of circulating tumor cells identifies SLIT2 as a regulator of metastasis

2 Sept 2022

Abstract excerpt

Circulating tumor cells (CTCs) break free from primary tumors and travel through the circulation system to seed metastatic tumors, which are the major cause of death from cancer. The identification of the major genetic factors that enhance production and persistence of CTCs in the bloodstream at a whole genome level would enable more comprehensive molecular mechanisms of metastasis to be elucidated and the...

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PMID: 36054348
DOI: 10.1126/sciadv.abo7792

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