Article
No anti-IgLON5 antibody in carefully diagnosed PSP patients with "atypical" or variant clinical features.
Parkinsonism & related disorders - 1 Nov 2025
Khairul Anuar Anis Nadhirah, Tan Ai Huey, Fernandiz Jeremy Christopher, Lim Yi Zhe, Fang Mimi S, Dy Closas Alfand Marl, Toh Tzi Shin, Lim Jia Lun, Ding Hans Xing, Abdul Sahak Akmal Mukhlis, Hor Jia Wei, Lit Lei Cheng, Lim Shen-Yang, McKeon Andrew B
Abstract excerpt
BACKGROUND: "Atypical" features including REM sleep behaviour disorder (RBD) symptoms and visual hallucinations, and non-Richardson's syndrome (non-RS) variants, are increasingly recognized in progressive supranuclear palsy (PSP). A concern in clinical practice is missing PSP mimics, like anti-IgLON5 disease, an autoimmune encephalitis which can reportedly present with "PSP-like" features and is amenable to...
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