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Paraneoplastic neuronal intermediate filament autoimmunity

3 Oct 2018

Abstract excerpt

Objective To describe paraneoplastic neuronal intermediate filament (NIF) autoimmunity. Methods Archived patient and control serum and CSF specimens were evaluated by tissue-based indirect immunofluorescence assay (IFA). Autoantigens were identified by Western blot and mass spectrometry. NIF specificity was confirmed by dual tissue section staining and 5 recombinant NIF-specific HEK293 cell-based assays (CBAs,...

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PMID: 30282771
DOI: 10.1212/wnl.0000000000006435

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