Article
Stiff person spectrum disorders: An illustrative case series of their phenotypic and antibody diversity.
Journal of neuroimmunology - 15 Apr 2020
Bernardo Francisco, Rebordão Leonor, Rêgo André, Machado Sara, Passos João, Costa Cristina, Cruz Simão, Pinto Amélia Nogueira, Santos Mariana
Abstract excerpt
Stiff person spectrum disorders (SPSD) are a broad group of immune-mediated disorders. Clinical presentations include classical stiff person syndrome (SPS), focal SPS, and progressive encephalomyelitis with rigidity and myoclonus (PERM). The most frequently associated antibodies are anti-GAD65, anti-GlyR, anti-amphiphysin, and anti-DPPX. Immunotherapy is the primary treatment modality. We present an illustrative...
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