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Article

Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA

18 Sept 2018

Abstract excerpt

Understanding mechanisms of late/acquired cancer immunotherapy resistance is critical to improve outcomes; cellular immunotherapy trials offer a means to probe complex tumor-immune interfaces through defined T cell/antigen interactions. We treated two patients with metastatic Merkel cell carcinoma with autologous Merkel cell polyomavirus specific CD8+ T cells and immune-checkpoint inhibitors. In both cases,...

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PMID: 30250229
DOI: 10.1038/s41467-018-06300-3

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