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Article

Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice.

American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2010

Miniati Doug, Jelin Eric B, Ng Jennifer, Wu Jianfeng, Carlson Timothy R, Wu Xiaoqing, Looney Mark R, Wang Rong A

Abstract excerpt

Lung arteriovenous (AV) shunts or malformations cause significant morbidity and mortality in several distinct clinical syndromes. For most patients with lung AV shunts, there is still no optimal treatment. The underlying molecular and cellular etiology for lung AV shunts remains elusive, and currently described animal models have insufficiently addressed this problem. Using a tetracycline-repressible system, we...

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Share to Arteriovenous Malformations
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelium, Vascular

Share to Models, Animal

Share to Receptor, Notch4

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Source

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Identifiers

PMID: 19933399
DOI: 10.1152/ajplung.00188.2009
PMCID: PMC2822562

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