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Article

Effect of CYP2D64, CYP2D610 polymorphisms on the safety of treatment with timolol maleate in patients with glaucoma.

Drug metabolism and personalized therapy - 1 Jun 2023

Moshetova Larisa K, Soshina Maria M, Turkina Ksenia I, Grishina Elena A, Sozaeva Zhannet A, Kachanova Anastasia A, Akmalova Kristina A, Ivashchenko Dmitriy V, Zastrozhin Mikhail S, Fisenko Vladimir P, Sychev Dmitry A

Abstract excerpt

OBJECTIVES: Timolol maleate is used for the treatment of glaucoma and metabolized by cytochrome CYP2D6 in the liver. The aim of this study was the evaluation of the influence of CYP2D6*4 and CYP2D6*10 gene polymorphisms on the safety of medications containing 0.5% of timolol maleate as glaucoma treatment in patients with primary open-angle glaucoma (POAG). METHODS: 105 patients with POAG were prescribed glaucoma...

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Share to Adrenergic beta-Antagonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 36001461
DOI: 10.1515/dmpt-2022-0117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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