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Article

Single-cell sequencing reveals novel cellular heterogeneity in uterine leiomyomas.

Human reproduction (Oxford, England) - 30 Sept 2022

Goad Jyoti, Rudolph Joshua, Zandigohar Mehrdad, Tae Matthew, Dai Yang, Wei Jian-Jun, Bulun Serdar E, Chakravarti Debabrata, Rajkovic Aleksandar

Abstract excerpt

STUDY QUESTION: What are the cellular composition and single-cell transcriptomic differences between myometrium and leiomyomas as defined by single-cell RNA sequencing? SUMMARY ANSWER: We discovered cellular heterogeneity in smooth muscle cells (SMCs), fibroblast and endothelial cell populations in both myometrium and leiomyoma tissues. WHAT IS KNOWN ALREADY: Previous studies have shown the presence of SMCs,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36001050
DOI: 10.1093/humrep/deac183
PMCID: PMC9802286

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