Article
Clinical Phenotypes of Patients With Systemic Sclerosis With Distinct Molecular Signatures in Skin.
Arthritis care & research - 1 Jul 2023
Yang Monica, Goh Vivien, Lee Jungwha, Espinoza Monica, Yuan Yiwei, Carns Mary, Aren Kathleen, Chung Lorinda, Khanna Dinesh, McMahan Zsuzsanna H, Agrawal Rishi, Nelson Lauren Beussink, Shah Sanjiv J, Whitfield Michael L, Hinchcliff Monique
Abstract excerpt
OBJECTIVE: Systemic sclerosis (SSc) patients are classified according to degree of skin fibrosis (limited and diffuse cutaneous [lc and dc]) and serum autoantibodies. We undertook the present multicenter study to determine whether intrinsic subset (IS) classification based upon skin gene expression yields additional valuable clinical information. METHODS: SSc patients and healthy participants (HPs) were...
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