Article
Rapid evolutionary turnover of mobile genetic elements drives bacterial resistance to phages.
Science (New York, N.Y.) - 22 Oct 2021
Hussain Fatima Aysha, Dubert Javier, Elsherbini Joseph, Murphy Mikayla, VanInsberghe David, Arevalo Philip, Kauffman Kathryn, Rodino-Janeiro Bruno Kotska, Gavin Hannah, Gomez Annika, Lopatina Anna, Le Roux Frédérique, Polz Martin F
Abstract excerpt
Although it is generally accepted that phages drive bacterial evolution, how these dynamics play out in the wild remains poorly understood. We found that susceptibility to viral killing in marine Vibrio is mediated by large and highly diverse mobile genetic elements. These phage defense elements display exceedingly fast evolutionary turnover, resulting in differential phage susceptibility among clonal bacterial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.