Article
Enhanced Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells in Ossification of the Posterior Longitudinal Ligament Through Activation of the BMP2-Smad1/5/8 Pathway.
Stem cells and development - 1 Dec 2020
Cai Zhaopeng, Wu Boyang, Ye Guiwen, Liu Wenjie, Chen Keng, Wang Peng, Xie Zhongyu, Li Jinteng, Zheng Guan, Yu Wenhui, Su Zepeng, Lin Jiajie, Wu Yanfeng, Shen Huiyong
Abstract excerpt
Ossification of the posterior longitudinal ligament (OPLL) is characterized by ectopic OPLL. To date, the specific molecular pathogenesis of OPLL has not been clearly elucidated. In this study, bone marrow-derived mesenchymal stem cells obtained from healthy donors (HD-MSCs) and patients with OPLL (OPLL-MSCs) were cultured in osteogenic differentiation medium for 21 days. The osteogenic differentiation capacity...
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