Article
Cytokine Mixtures Mimicking the Local Milieu in Patients with Inflammatory Bowel Disease Impact Phenotype and Function of Mesenchymal Stromal Cells.
Stem cells translational medicine - 21 Sept 2022
Barnhoorn Marieke C, van der Meulen-de Jong Andrea E, Schrama Ellen C L M, Plug Leonie G, Verspaget Hein W, Fibbe Willem E, van Pel Melissa, Hawinkels Lukas J A C, Schepers Koen
Abstract excerpt
Locally applied mesenchymal stromal cells (MSCs) have the capacity to promote the healing of perianal fistulas in Crohn's disease (CD) and are under clinical development for the treatment of proctitis in ulcerative colitis (UC). Despite these clinical advances, the mechanism of action of local MSC therapy in inflammatory bowel disease (IBD) is largely unknown. We hypothesized that the local cytokine environment...
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