Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters show stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It.

doi:10.3390/ijms21031045

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Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters show stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It.

International journal of molecular sciences - 5 Feb 2020

Ponomarenko Mikhail, Rasskazov Dmitry, Chadaeva Irina, Sharypova Ekaterina, Drachkova Irina, Oshchepkov Dmitry, Ponomarenko Petr, Savinkova Ludmila, Oshchepkova Evgeniya, Nazarenko Maria, Kolchanov Nikolay

Abstract excerpt

(1) Background: The World Health Organization (WHO) regards atherosclerosis-related myocardial infarction and stroke as the main causes of death in humans. Susceptibility to atherogenesis-associated diseases is caused by single-nucleotide polymorphisms (SNPs). (2) Methods: Using our previously developed public web-service SNP_TATA_Comparator, we estimated statistical significance of the SNP-caused alterations in...

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PMID: 32033288
DOI: 10.3390/ijms21031045
PMCID: PMC7037642

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