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Article

A gene expression assay based on chronic lymphocytic leukemia activation in the microenvironment to predict progression.

Blood advances - 8 Nov 2022

Abrisqueta Pau, Medina Daniel, Villacampa Guillermo, Lu Junyan, Alcoceba Miguel, Carabia Julia, Boix Joan, Tazón-Vega Barbara, Iacoboni Gloria, Bobillo Sabela, Marín-Niebla Ana, González Marcos, Zenz Thorsten, Crespo Marta, Bosch Francesc

Abstract excerpt

Several gene expression profiles with a strong correlation with patient outcomes have been previously described in chronic lymphocytic leukemia (CLL), although their applicability as biomarkers in clinical practice has been particularly limited. Here we describe the training and validation of a gene expression signature for predicting early progression in patients with CLL based on the analysis of 200 genes...

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Identifiers

PMID: 35973197
DOI: 10.1182/bloodadvances.2022007508
PMCID: PMC9647836

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