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Development and Validation of the PREMMplus Model for Multigene Hereditary Cancer Risk Assessment.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Dec 2022

Yurgelun Matthew B, Uno Hajime, Furniss C Sloane, Ukaegbu Chinedu, Horiguchi Miki, Yussuf Amal, LaDuca Holly, Chittenden Anu, Garber Judy E, Syngal Sapna

Abstract excerpt

PURPOSE: With the availability of multigene panel testing (MGPT) for hereditary cancer risk assessment, clinicians need to assess the likelihood of pathogenic germline variants (PGVs) across numerous genes in parallel. This study's aim was to develop and validate a clinical prediction model (PREMMplus) for MGPT risk assessment. MATERIALS AND METHODS: PREMMplus was developed in a single-institution cohort of 7,280...

Topics

Humans
Genetic Predisposition to Disease
Models, Statistical
Prognosis
Neoplasms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35960913
DOI: 10.1200/JCO.22.00120
PMCID: PMC9746785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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