Melatonin antagonizes cadmium‐induced neurotoxicity by activating the transcription factor <scp>EB</scp>‐dependent autophagy–lysosome machinery in mouse neuroblastoma cells

Abstract excerpt

Cadmium (Cd), a highly ubiquitous heavy metal, induces neurotoxicity. Melatonin, a major secretory product of the pineal gland, protects against Cd-induced neurotoxicity. However, the mechanism that accounts for this protection remains to be elucidated. Herein, we exposed mouse neuroblastoma cells (Neuro-2a cells) to different concentrations of cadmium chloride (CdCl2 ) (12.5, 25, and 50 μ mol L(-1) ) for 24...

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