Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutated FANCA Gene Role in the Modulation of Energy Metabolism and Mitochondrial Dynamics in Head and Neck Squamous Cell Carcinoma

30 Jul 2022

Abstract excerpt

Fanconi Anaemia (FA) is a rare recessive genetic disorder characterized by a defective DNA repair mechanism. Although aplastic anaemia is the principal clinical sign in FA, patients develop a head and neck squamous cell carcinoma (HNSCC) with a frequency 500–700 folds higher than the general population, which appears more aggressive, with survival of under two years. Since FA gene mutations are also associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to DNA Repair Mechanisms
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35954197
DOI: 10.3390/cells11152353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutated FANCA Gene Role in the Modulation of Energy Metabolism and Mitochondrial Dynamics in Head and Neck Squamous Cell CarcinomaPMID 35954197Read ↗

Head and Neck Cancer Susceptibility and Metabolism in Fanconi AnemiaSemantic proximity Read ↗

Squamous cell carcinomas of the head and neck in Fanconi anemia: risk, prevention, therapy, and the need for guidelines.Semantic proximity Read ↗

Mitochondrial respiratory chain Complex I defects in Fanconi anemia complementation group A.Semantic proximity Read ↗

Two enemies, one fight: An update of oral cancer in patients with Fanconi anemiaSemantic proximity Read ↗

The Fanconi anaemia genome stability and tumour suppressor network.Semantic proximity Read ↗

Mitochondrial DNA variations and mitochondrial dysfunction in Fanconi anemia.Semantic proximity Read ↗

The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma.Semantic proximity Read ↗

Diagnosis and Treatment for Squamous Cell Carcinoma of the Oral Tongue in a Patient with Fanconi AnemiaSemantic proximity Read ↗

Defective cell proliferation is an attribute of overexpressed Notch1 receptor and impaired autophagy in Fanconi Anemia.Semantic proximity Read ↗

Metabolic cell death of labile iron deficiency as a vulnerability of head and neck squamous cell carcinoma evaded by BACH1Semantic proximity Read ↗

Emerging functions of the Fanconi anemia pathway at a glance.Semantic proximity Read ↗

Re-definition and supporting evidence toward Fanconi Anemia as a mitochondrial disease: Prospects for new design in clinical management.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.