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Article

Defective cell proliferation is an attribute of overexpressed Notch1 receptor and impaired autophagy in Fanconi Anemia.

Genomics - 1 Nov 2020

Zipporah E Binita, Patra Bamadeb, Govarthanan Kavitha, Yadav Rajesh, Mohan Sheila, Shyamsunder Pavithra, Verma Rama Shanker

Abstract excerpt

Fanconi Anemia (FA) is an inherited bone marrow failure syndrome caused by mutation in FA pathway proteins, involved in Interstrand Cross Link (ICL) repair. FA cells exhibit in vitro proliferation arrest due to accumulated DNA damage, hence understanding the rescue mechanism that renders proliferation advantage is required. Gene expression profiling performed in FA patients Peripheral Blood Mononuclear Cells...

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Identifiers

PMID: 32800766
DOI: 10.1016/j.ygeno.2020.08.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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