Article

Metabolic cell death of labile iron deficiency as a vulnerability of head and neck squamous cell carcinoma evaded by BACH1

2025-04-11

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) remains difficult to treat due to the lack of molecularly targeted drugs with high anti-tumor efficacy and safety. To investigate the involvement of the transcription factor BACH1, which is known to promote the metastasis of various cancers, in the malignant properties of HNSCC cells, we examined the effects of BACH1 depletion with short interfering RNAs in human HNSCC...

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Literature Corpus work: 7b1419f7-3699-5edd-a56a-8528307965eb
DOI: 10.1101/2025.04.07.647470

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