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Article

Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium

14 Jul 2022

Abstract excerpt

Differences in ciliary morphology and dynamics among multiciliated cells of the respiratory tract contribute to efficient mucociliary clearance. Nevertheless, little is known about how these phenotypic differences are established. We show that Prominin 1 (Prom1), a transmembrane protein widely used as stem cell marker, is crucial to this process. During airway differentiation, Prom1 becomes restricted to...

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PMID: 35942101
DOI: 10.1016/j.isci.2022.104751

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