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Detection of DNA copy number alterations by matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of single nucleotide polymorphisms.

Clinical chemistry and laboratory medicine - 27 Sept 2022

Jin Shengnan, Huang Dan, Jin Weijiang, Wang Yourong, Shao Hengrong, Gong Lisha, Luo Zhenni, Yang Zhengquan, Luan Ju, Xie Deyao, Ding Chunming

Abstract excerpt

OBJECTIVES: Copy number alterations (CNAs) are frequently found in malignant tissues. Different approaches have been used for CNA detection. However, it is not easy to detect a large panel of CNA targets in heterogenous tumors. METHODS: We have developed a CNAs detection approach through quantitatively analyzed allelic imbalance by allelotyping single nucleotide polymorphisms (SNPs) by matrix-assisted laser...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35938948
DOI: 10.1515/cclm-2022-0511

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