Article
Interrogation of genomes by molecular copy-number counting (MCC).
Nature methods - 1 Jun 2006
Daser Angelika, Thangavelu Madan, Pannell Richard, Forster Alan, Sparrow Louise, Chung Grace, Dear Paul H, Rabbitts Terence H
Abstract excerpt
Human cancers and some congenital traits are characterized by cytogenetic aberrations including translocations, amplifications, duplications or deletions that can involve gain or loss of genetic material. We have developed a simple method to precisely delineate such regions with known or cryptic genomic alterations. Molecular copy-number counting (MCC) uses PCR to interrogate miniscule amounts of genomic DNA and...
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