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Article

Rotational Symmetry of Two Pyrethroid Receptor Sites in the Mosquito Sodium Channel.

Molecular pharmacology - 1 Aug 2015

Du Yuzhe, Nomura Yoshiko, Zhorov Boris S, Dong Ke

Abstract excerpt

Voltage-gated sodium channels are the primary target of pyrethroid insecticides. Although it is well known that specific mutations in insect sodium channels confer knockdown resistance (kdr) to pyrethroids, the atomic mechanisms of pyrethroid-sodium channel interactions are not clearly understood. Previously, computer modeling and mutational analysis predicted two pyrethroid receptors, pyrethroid receptor site 1...

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Identifiers

PMID: 25972447
DOI: 10.1124/mol.115.098707
PMCID: PMC4518084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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