miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2.

doi:10.1172/jci.insight.121781

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2.

JCI insight - 16 Jan 2020

Fuentes-Mattei Enrique, Bayraktar Recep, Manshouri Taghi, Silva Andreia M, Ivan Cristina, Gulei Diana, Fabris Linda, Soares do Amaral Nayra, Mur Pilar, Perez Cristina, Torres-Claudio Elizabeth, Dragomir Mihnea P, Badillo-Perez Adriana, Knutsen Erik, Narayanan Pranav, Golfman Leonard, Shimizu Masayoshi, Zhang Xinna, Zhao Wanke, Ho Wanting Tina, Estecio Marcos Roberto, Bartholomeusz Geoffrey, Tomuleasa Ciprian, Berindan-Neagoe Ioana, Zweidler-McKay Patrick A, Estrov Zeev, Zhao Zhizhuang J, Verstovsek Srdan, Calin George A, Redis Roxana S

Abstract excerpt

Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by cytopenia and extramedullary hematopoiesis, resulting in splenomegaly. Multiple pathological mechanisms (e.g., circulating cytokines and genetic alterations, such as JAKV617F mutation) have been implicated in the etiology of MF, but the molecular mechanism causing resistance to JAK2V617F inhibitor therapy remains unknown. Among MF patients who...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dioxygenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinases

Share to Mixed Function Oxygenases

Share to Myeloproliferative Disorders

Share to Nitriles

Share to Primary Myelofibrosis

Share to Pyrazoles

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 31941838
DOI: 10.1172/jci.insight.121781
PMCID: PMC7030823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-543 regulates the epigenetic landscape of myelofibrosis by targeting TET1 and TET2.PMID 31941838Read ↗

An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis.Semantic proximity Read ↗

Epigenetic Function of TET Family, 5-Methylcytosine, and 5-Hydroxymethylcytosine in Hematologic MalignanciesSemantic proximity Read ↗

Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes.Semantic proximity Read ↗

Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib.Semantic proximity Read ↗

Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCsSemantic proximity Read ↗

Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis.Semantic proximity Read ↗

JAK1/2 inhibition impairs T cell function in vitro and in patients with myeloproliferative neoplasms.Semantic proximity Read ↗

Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic neoplasm in mice.Semantic proximity Read ↗

TET1 is a tumor suppressor of hematopoietic malignancy.Semantic proximity Read ↗

IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia.Semantic proximity Read ↗

The TET2 interactors and their links to hematological malignancies.Semantic proximity Read ↗

Dysregulation of TET2 in hematologic malignancies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.