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Article

SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity.

Stem cells (Dayton, Ohio) - 1 Jan 2009

Gangemi Rosaria Maria Rita, Griffero Fabrizio, Marubbi Daniela, Perera Marzia, Capra Maria Cristina, Malatesta Paolo, Ravetti Gian Luigi, Zona Gian Luigi, Daga Antonio, Corte Giorgio

Abstract excerpt

Glioblastoma, the most aggressive cerebral tumor, is invariably lethal. Glioblastoma cells express several genes typical of normal neural stem cells. One of them, SOX2, is a master gene involved in sustaining self-renewal of several stem cells, in particular neural stem cells. To investigate its...

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Source

Identifiers

PMID: 18948646
DOI: 10.1634/stemcells.2008-0493

Genes

SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18948646-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity.PMID 18948646Read ↗

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