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Article

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma

1 Jan 2017

Abstract excerpt

Efforts to identify and target glioblastoma (GBM) drivers have primarily focused on receptor tyrosine kinases (RTKs). Clinical benefits, however, have been elusive. Here, we identify an SRY-related box 2 (SOX2) transcriptional regulatory network that is independent of upstream RTKs and capable of driving glioma-initiating cells. We identified oligodendrocyte lineage transcription factor 2 (OLIG2) and zinc-finger...

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PMID: 28122245
DOI: 10.1016/j.celrep.2016.12.064

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