Article
TP53 mutation detected in circulating exosomal DNA is associated with prognosis of patients with hepatocellular carcinoma.
Cancer biology & therapy - 31 Dec 2022
Li Yong, Wu Junjun, Li Enliang, Xiao Zhouqing, Lei Jun, Zhou Fan, Yin Xiangbao, Hu Dandan, Mao Yilei, Wu Linquan, Wenjun Liao
Abstract excerpt
Exosome DNA (exoDNA) can be used for liquid biopsy. This study was the first to use droplet digital PCR (ddPCR) to detect tumor-specific mutations in exoDNA and to evaluate the prognosis of hepatocellular carcinoma (HCC) patients. 60 HCC patients were enrolled in the study. We used ddPCR to detect c.747 G > T mutation in TP53 gene. We analyzed the correlation between detectable mutation in exoDNA and...
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