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Article

Quantitative detections of TP53 gene mutations improve the diagnosis and prognostic prediction of biliary tract cancers using droplet digital PCR.

Journal of clinical laboratory analysis - 1 Jan 2022

Xiao Xiao, Zhou Jun, Fang Meng, Ji Jun, Huang Chenjun, Du Fei, Ai Wenchao, Wang Ying, Gao Zhiyuang, Qiu Zhiquan, Gao Chunfang

Abstract excerpt

OBJECTIVE: Biliary tract cancer (BTC) is a rare malignancy and lack of effective diagnostic and prognostic marker. Here, we aimed to investigate the clinical implication of TP53 mutation detection in BTC using droplet digital PCR (ddPCR). METHODS: TP53 gene (loci p.R175H, p.R248Q, p.R248W, and p.R273H) mutation frequencies of 45 pairs of tumor tissues (TTs) and adjacent normal tissues (ANTTs) were analyzed,...

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Identifiers

PMID: 34813121
DOI: 10.1002/jcla.24103
PMCID: PMC8761443

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