Article
Early symptoms in symptomatic and preclinical genetic frontotemporal lobar degeneration.
Journal of neurology, neurosurgery, and psychiatry - 1 Sept 2020
Tavares Tamara Paulo, Mitchell Derek G V, Coleman Kristy Kl, Coleman Brenda L, Shoesmith Christen L, Butler Christopher R, Santana Isabel, Danek Adrian, Gerhard Alexander, de Mendonca Alexandre, Borroni Barbara, Tartaglia Maria Carmela, Graff Caroline, Galimberti Daniela, Tagliavini Fabrizio, Moreno Fermin, Frisoni Giovanni, Rowe James Benedict, Levin Johannes, Van Swieten John Cornelis, Otto Markus, Synofzik Matthis, Sanchez-Valle Raquel, Vandenberghe Rik, Laforce Robert Jr, Ghidoni Roberta, Sorbi Sandro, Ducharme Simon, Masellis Mario, Rohrer Jonathan, Finger Elizabeth
Abstract excerpt
OBJECTIVES: The clinical heterogeneity of frontotemporal dementia (FTD) complicates identification of biomarkers for clinical trials that may be sensitive during the prediagnostic stage. It is not known whether cognitive or behavioural changes during the preclinical period are predictive of genetic status or conversion to clinical FTD. The first objective was to evaluate the most frequent initial symptoms in...
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