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Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness

1 Mar 2022

Abstract excerpt

Aims: Long-chain polyunsaturated fatty acids (PUFAs) generate diverse bioactive lipid mediators, which tightly regulate vascular inflammation. The effects of omega-3 PUFA supplementation in cardiovascular prevention however remain controversial. In addition to direct dietary intake, fatty acid desaturases (FADS) determine PUFA levels. Increased arterial stiffness represents an independent predictor of mortality...

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PMID: 35919123
DOI: 10.1093/ehjopen/oeac016

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