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Article

A Variant Allele in Varicella-Zoster Virus Glycoprotein B Selected during Production of the Varicella Vaccine Contributes to Its Attenuation.

mBio - 30 Aug 2022

Sadaoka Tomohiko, Depledge Daniel P, Rajbhandari Labchan, Breuer Judith, Venkatesan Arun, Cohen Jeffrey I

Abstract excerpt

Attenuation of the live varicella Oka vaccine (vOka) has been attributed to mutations in the genome acquired during cell culture passage of pOka (parent strain); however, the precise mechanisms of attenuation remain unknown. Comparative sequence analyses of several vaccine batches showed that over 100 single-nucleotide polymorphisms (SNPs) are conserved across all vaccine batches; 6 SNPs are nearly fixed,...

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Identifiers

PMID: 35916400
DOI: 10.1128/mbio.01864-22
PMCID: PMC9426484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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