Article
Deep sequencing of viral genomes provides insight into the evolution and pathogenesis of varicella zoster virus and its vaccine in humans.
Molecular biology and evolution - 1 Feb 2014
Depledge Daniel P, Kundu Samit, Jensen Nancy J, Gray Eleanor R, Jones Meleri, Steinberg Sharon, Gershon Anne, Kinchington Paul R, Schmid D Scott, Balloux Francois, Nichols Richard A, Breuer Judith
Abstract excerpt
Immunization with the vOka vaccine prevents varicella (chickenpox) in children and susceptible adults. The vOka vaccine strain comprises a mixture of genotypes and, despite attenuation, causes rashes in small numbers of recipients. Like wild-type virus, the vaccine establishes latency in neuronal tissue and can later reactivate to cause Herpes zoster (shingles). Using hybridization-based methodologies, we have...
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