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Article

The attenuated genotype of varicella-zoster virus includes an ORF0 transitional stop codon mutation.

Journal of virology - 1 Oct 2012

Peters Geoffrey A, Tyler Shaun D, Carpenter John E, Jackson Wallen, Mori Yasuko, Arvin Ann M, Grose Charles

Abstract excerpt

Varicella-zoster virus (VZV) is the first of the human herpesviruses to be attenuated and subsequently approved as a live vaccine to prevent varicella and herpes zoster. Both the attenuated VZV vaccine, called vaccine Oka or vOka, and the parental strain pOka have been completely sequenced. Yet the specific determinants of attenuation are uncertain. The open reading frame (ORF) with the most single nucleotide...

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Identifiers

PMID: 22837206
DOI: 10.1128/JVI.01067-12
PMCID: PMC3457260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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