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Article

The live attenuated varicella-zoster virus vaccine vOka: Molecular and cellular biology of its skin attenuation.

Human vaccines & immunotherapeutics - 1 Dec 2025

Tommasi Cristina, Drousioti Andriani, Breuer Judith

Abstract excerpt

Infection with varicella-zoster virus (VZV) causes chickenpox and shingles, both manifesting as a blistering skin rash. The skin is central to VZV, as the site of viral replication, transmission from cell-free virus in blisters and as the gateway to sensory nerves for establishing latency. The existing chickenpox vaccine is based on the live attenuated vOka strain and is impaired for replication in skin. While...

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Identifiers

PMID: 40153527
DOI: 10.1080/21645515.2025.2482286
PMCID: PMC11959904

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