Article
Natural selection for rash-forming genotypes of the varicella-zoster vaccine virus detected within immunized human hosts.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jan 2007
Quinlivan Mark L, Gershon Anne A, Al Bassam Mahmoud M, Steinberg Sharon P, LaRussa Philip, Nichols Richard A, Breuer Judith
Abstract excerpt
The Oka vaccine strain is a live attenuated virus that is routinely administered to children in the United States and Europe to prevent chickenpox. It is effective and safe but occasionally produces a rash. The vaccine virus has accumulated mutations during its attenuation, but the rashes are not explained by their reversion, unlike complications reported for other viral vaccines. Indeed, most of the novel...
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