Article
Deep Sequencing of Distinct Preparations of the Live Attenuated Varicella-Zoster Virus Vaccine Reveals a Conserved Core of Attenuating Single-Nucleotide Polymorphisms.
Journal of virology - 1 Oct 2016
Depledge Daniel P, Yamanishi Koichi, Gomi Yasuyuki, Gershon Anne A, Breuer Judith
Abstract excerpt
UNLABELLED: The continued success of the live attenuated varicella-zoster virus vaccine in preventing varicella-zoster and herpes zoster is well documented, as are many of the mutations that contribute to the attenuation of the vOka virus for replication in skin. At least three different preparations of vOka are marketed. Here, we show using deep sequencing of seven batches of vOka vaccine (including ZostaVax,...
Topics
- Chickenpox Vaccine
- Herpesvirus 3, Human
- High-Throughput Nucleotide Sequencing
- Polymorphism, Single Nucleotide
- Vaccines, Attenuated
- Virulence