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Hypoxia-induced circWSB1 promotes breast cancer progression through destabilizing p53 by interacting with USP10

29 Mar 2022

Abstract excerpt

BACKGROUND: Hypoxia has long been considered as a hallmark of solid tumors and is closely associated with tumor progression. Circular RNAs (circRNAs) have been identified as a critical modulator in various cancers. However, the connections between hypoxia and circRNAs are largely unknown. METHODS: Here, we investigated the expression profile of circRNAs in breast cancer (BC) MCF-7 cells under hypoxia and normoxia...

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PMID: 35351136
DOI: 10.1186/s12943-022-01567-z

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