Article
Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle.
Molecular genetics & genomic medicine - 1 Sept 2022
Djuric Tamara, Kuveljic Jovana, Djordjevic Ana, Dekleva Milica, Stankovic Goran, Stankovic Aleksandra, Zivkovic Maja
Abstract excerpt
BACKGROUND: Myocardial infarction (MI) leads to ischemia and afterward to left ventricular (LV) remodeling. Matrix metalloproteinase-1 (MMP1) and -3 (MMP3) belong to the family of endopeptidases and together they can dissolve most of the components of the extracellular matrix. MMP1 and MMP3 variants have been investigated solely in association with ischemic heart disease and LV dysfunction, but not in haplotype....
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