Article
Requirement for TP73 and genetic alterations originating from its intragenic super-enhancer in adult T-cell leukemia.
Leukemia - 1 Sept 2022
Ong Jolynn Zu Lin, Yokomori Rui, Wong Regina Wan Ju, Tan Tze King, Ueda Ryuzo, Ishida Takashi, Iida Shinsuke, Sanda Takaomi
Abstract excerpt
Adult T-cell leukemia/lymphoma (ATL) is a genetically complex hematological malignancy derived from mature T cells. Using an integrative approach, we previously identified genes recurrently associated with super-enhancers in ATL. One of those genes was TP73, a TP53 family gene; however, the roles and function of TP73 and its super-enhancer in ATL pathogenesis are poorly understood. Our study demonstrates that...
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