Article
Effects of GBA1 Variants in Patients With Parkinson's Disease and Levodopa-Carbidopa Intestinal Gel: A Nation-Wide, Multicenter, Longitudinal, "Real-World" Study. The EPIC Study.
European journal of neurology - 1 Jul 2025
Cilia Roberto, Colucci Fabiana, Cereda Emanuele, Elia Antonio E, Leta Valentina, Barca Silvia, Zibetti Maurizio, Carecchio Miryam, Bonvegna Salvatore, Calandra-Buonaura Giovanna, Cerroni Rocco, De Micco Rosa, Tamburin Stefano, Magistrelli Luca, Lena Francesco, Mascia Marcello M, Picillo Marina, Cossu Giovanni, Marano Massimo, Zampogna Alessandro, Pellicano Clelia, Fioravanti Valentina, Pilotto Andrea, Zangaglia Roberta, Avenali Micol, Sorbera Chiara, Di Biasio Francesca, Arienti Federica, Nicoletti Alessandra, Bagella Caterina, Malaguti Maria Chiara, Ranghetti Alessandra, Caputo Elena, Alimonti Dario, Torre Elena, Oggioni Gaia D, Leuzzi Catia, Romito Luigi M, Andreasi Nico Golfrè, Devigili Grazia, Telese Roberta, Braccia Arianna, Gaudiano Gianfranco, Mazzetti Samanta, Invernizzi Federica, Garavaglia Barbara, Imbalzano Gabriele, Ledda Claudia, Antenucci Pietro, Gozzi Andrea, Bonato Giulia, Percetti Marco, Giannini Giulia, Sambati Luisa, Schirinzi Tommaso, D'Anna Martina, Rinaldi Domiziana, Cavallieri Francesco, Liccari Marco, Priori Alberto, Sessa Maria, Tamma Filippo, Canesi Margherita, Solla Paolo, Zappia Mario, Di Fonzo Alessio, Avanzino Laura, Quartarone Angelo, Valente Enza Maria, Pacchetti Claudio, Padovani Alessandro, Valzania Franco, Pontieri Francesco E, Suppa Antonio, Pellecchia Maria Teresa, Modugno Nicola, Comi Cristoforo, Tinazzi Michele, Tessitore Alessandro, Stefani Alessandro, Cortelli Pietro, Isaias Ioannis U, Antonini Angelo, Sensi Mariachiara, Lopiano Leonardo, Eleopra Roberto
Abstract excerpt
BACKGROUND: The outcome of levodopa/carbidopa intestinal gel (LCIG) in Parkinson's disease carriers of GBA1 mutations (GBA-PD) remains uncertain. OBJECTIVE: To evaluate the safety and efficacy of LCIG in a large PD cohort, focusing on GBA1 variants. METHODS: This multicenter, retrospective, longitudinal "real-world" study included consecutive patients with advanced PD treated with LCIG at 31 Italian centers; data...
