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Article

Constancy and diversity in the flavivirus fusion peptide

1 Jan 2008

Abstract excerpt

BACKGROUND: Flaviviruses include the mosquito-borne dengue, Japanese encephalitis, yellow fever and West Nile and the tick-borne encephalitis viruses. They are responsible for considerable world-wide morbidity and mortality. Viral entry is mediated by a conserved fusion peptide containing 16 amino acids located in domain II of the envelope protein E. Highly orchestrated conformational changes initiated by...

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PMID: 18275613
DOI: 10.1186/1743-422x-5-27

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