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Novel ryanodine receptor 1 (RYR1) missense gene variants in two pet dogs with fatal malignant hyperthermia identified by next-generation sequencing.

Veterinary anaesthesia and analgesia - 1 Jan 2000

Perez Jimenez Tania E, Issaka Salia Ousseini, Neibergs Holly L, Zhu Zhaohui, Spoor Erich, Rider Chaley, Court Michael H

Abstract excerpt

OBJECTIVE: Evaluate a precision medicine approach to confirm a tentative diagnosis of fatal malignant hyperthermia (MH) in isoflurane-anesthetized pet dogs by identifying novel risk variants in known MH susceptibility genes. STUDY DESIGN: Retrospective case series. ANIMALS: A male Pit Bull mix aged 7 years (case #1), a male Golden Retriever aged 12 months (case #2) and the dam and sire of case #2. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39516111
DOI: 10.1016/j.vaa.2024.10.131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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