Article
A RAPGEF6 variant constitutes a major risk factor for laryngeal paralysis in dogs.
PLoS genetics - 1 Oct 2019
Hadji Rasouliha Sheida, Barrientos Laura, Anderegg Linda, Klesty Carina, Lorenz Jessica, Chevallier Lucie, Jagannathan Vidhya, Rösch Sarah, Leeb Tosso
Abstract excerpt
Laryngeal paralysis (LP) is the inability to abduct the arytenoid cartilages during inspiration, resulting in a partial to complete airway obstruction and consequent respiratory distress. Different forms of LP with varying age of onset exist in dogs. Hereditary early onset forms were reported in several dog breeds. In most breeds, hereditary LP is associated with other neurologic pathologies. Using a genome-wide...
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