Higher-fitness yeast genotypes are less robust to deleterious mutations.

doi:10.1126/science.aay4199

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Article

Higher-fitness yeast genotypes are less robust to deleterious mutations.

Science (New York, N.Y.) - 25 Oct 2019

Johnson Milo S, Martsul Alena, Kryazhimskiy Sergey, Desai Michael M

Abstract excerpt

Natural selection drives populations toward higher fitness, but second-order selection for adaptability and mutational robustness can also influence evolution. In many microbial systems, diminishing-returns epistasis contributes to a tendency for more-fit genotypes to be less adaptable, but no an...

Topics

Epistasis, Genetic
Genetic Fitness
Genotype
Models, Genetic
Mutagenesis, Insertional
Saccharomyces cerevisiae
Selection, Genetic

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