Article
Higher-fitness yeast genotypes are less robust to deleterious mutations.
Science (New York, N.Y.) - 25 Oct 2019
Johnson Milo S, Martsul Alena, Kryazhimskiy Sergey, Desai Michael M
Abstract excerpt
Natural selection drives populations toward higher fitness, but second-order selection for adaptability and mutational robustness can also influence evolution. In many microbial systems, diminishing-returns epistasis contributes to a tendency for more-fit genotypes to be less adaptable, but no analogous patterns for robustness are known. To understand how robustness varies across genotypes, we measure the fitness...
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